As spatial biomarker programs move into translational and clinical research, researchers need to refine broad biological questions into focused panels—often working from limited, precious samples where panel reliability is essential. Designing those panels requires careful consideration of which biomarkers to measure, how they perform together, and how the panel can be adapted as the research program evolves.
On the Orion™ spatial proteomics platform, up to 18 biomarkers are measured in a single round of staining and imaging. There is no staining order to determine, and the single-round workflow preserves antigen and tissue integrity. Biomarkers can be drawn from a portfolio of 600+ IHC-validated conjugates that share one antigen retrieval condition, so they can be combined into any panel. Custom biomarkers can be added through ArgoFluor™ conjugation kits or RareCyte's conjugation service.
In this 30-minute practical session, RareCyte Field Application Scientist Mickael Meyrand will demonstrate how to translate a biological research question into a custom spatial biomarker panel on Orion. The session introduces the Orion Panel Designer and shows how it configures a panel and assigns each biomarker to its optimal channel.
What you'll see:
- How recent advances in mIF address previous hurdles, including: lack of validated reagents; limited ability to add custom biomarkers; high cost and low throughput associated with detecting more markers in large volume clinical trials
- How incorporation of immune response biomarkers with target biomarkers provides more comprehensive insights
- How Orion simplifies panel development, featuring a live demo of the Panel Designer
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Mickael obtained a Master's degree in Biology from the Ecole Pratique des Hautes Etudes in Paris, and has tenured work experience in diverse research academic institutions in France and the United States specializing in instrument operations. Mickael has been continuously supporting customer success with cutting edge technologies in the field of cell biology imaging since 2014.
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Mickael obtained a Master's degree in Biology from the Ecole Pratique des Hautes Etudes in Paris, and has tenured work experience in diverse research academic institutions in France and the United States specializing in instrument operations. Mickael has been continuously supporting customer success with cutting edge technologies in the field of cell biology imaging since 2014.
LinkedIn Profile →